The paracellular channel: biology, physiology, and disease

'The Paracellular Channel' offers a cohesive and unifying picture of the critical functions of paracellular channels (tight junctions) in different tissues.

This new class of ion channel utilises a completely different mechanism to create ion passage pathways across the cell junction.

This volume outlines common principles that govern the organisation and regulation of these diverse cellular structures, describes the methodology of study, and highlights the pathophysiologic consequence of abnormal structure and functions of the paracellular channels in human diseases.

Coverage includes biochemical, biophysical, structural, physiologic analyses of the paracellular channel, and new technologies for recording and characterisation.