Antimalarial Agents: Design and Mechanism of Action seeks to support medicinal chemists in their work towards antimalarial solution, providing practical guidance on current developments and highlighting promising leads for the future. Malaria is a deadly disease which threatens half of the world's population.
Advances over the last decade have seen vast improvements in the effectiveness of both preventative measures and treatments, but the rapid adaptability of the disease means that the ongoing search for improved and novel antimalarial drugs is essential. Beginning with a focus on biological aspects of malaria, this book highlights the lifecycle of the parasite responsible for malaria, the problem of resistance, genetic mapping of the parasite's genome, established drug targets, and potential drug targets for the future.
The book also includes detailed study of the medicinal chemistry of antimalarial agents and a focus on the design of antimalarial drugs. Drawing on the knowledge of its expert authors and coupling historic research with current findings to provide a full picture of both past and current milestones, Antimalarial Agents: Design and Mechanism of Action is a comprehensive yet accessible guide for all those involved in the design, development and administration of antimalarial drugs, including academic researchers, medicinal chemists, malaria researchers and pharmaceutical scientists.