Palladium and Nickel Catalyzed Transformations Forming Functionalized Dihydroisoquinolinones, Chromans, Dihydrobenzofurans and Oxindoles
(1st ed. 2020)
Part of the SPRINGER THESES series
This book presents Pd- and Ni-catalyzed transformations generating functionalized heterocycles.
Transition metal catalysis is at the forefront of synthetic organic chemistry since it offers new and powerful methods to forge carbon-carbon bonds in high atom- and step-economy.
In Chapter 1, the author describes a Pd- and Ni-catalyzed cycloisomerization of aryl iodides to alkyl iodides, known as carboiodination.
In the context of the Pd-catalyzed variant, the chapter explores the production of enantioenriched carboxamides through diastereoselective Pd-catalyzed carboiodination.
It then discusses Ni-catalyzed reactions to generate oxindoles and an enantioselective variant employing a dual ligand system.
Chapter 2 introduces readers to a Pd-catalyzed diastereoselective anion-capture cascade.
It also examines diastereoselective Pd-catalyzed aryl cyanation to synthesize alkyl nitriles, a method that generates high yields of borylated chromans as a single diastereomer, and highlights its synthetic utility. Lastly, Chapter 3 presents a Pd-catalyzed domino process harnessing carbopalladation, C-H activation and -system insertion (benzynes and alkynes) to generate spirocycles.
It also describes the mechanistic studies performed on these reactions.