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Palladium and Nickel Catalyzed Transformations Forming Functionalized Dihydroisoquinolinones, Chromans, Dihydrobenzofurans and Oxindoles (1st ed. 2020)

By: Yoon, Hyung

Part of the SPRINGER THESES series
3030540766 / 9783030540760
Hardback
26/10/2020
Published 26/10/2020
Switzerland
155 x 235 mm 237 pages, 35 Illustrations, color; 517 Illustrations, black and white; XXIX, 237 p. 552 illus., 35
Professional & Vocational  Learn More

This book presents Pd- and Ni-catalyzed transformations generating functionalized heterocycles.

Transition metal catalysis is at the forefront of synthetic organic chemistry since it offers new and powerful methods to forge carbon-carbon bonds in high atom- and step-economy.

In Chapter 1, the author describes a Pd- and Ni-catalyzed cycloisomerization of aryl iodides to alkyl iodides, known as carboiodination.

In the context of the Pd-catalyzed variant, the chapter explores the production of enantioenriched carboxamides through diastereoselective Pd-catalyzed carboiodination.

It then discusses Ni-catalyzed reactions to generate oxindoles and an enantioselective variant employing a dual ligand system.

Chapter 2 introduces readers to a Pd-catalyzed diastereoselective anion-capture cascade.

It also examines diastereoselective Pd-catalyzed aryl cyanation to synthesize alkyl nitriles, a method that generates high yields of borylated chromans as a single diastereomer, and highlights its synthetic utility. Lastly, Chapter 3 presents a Pd-catalyzed domino process harnessing carbopalladation, C-H activation and -system insertion (benzynes and alkynes) to generate spirocycles.

It also describes the mechanistic studies performed on these reactions.

BIC:

PNK Inorganic chemistry, PNN Organic chemistry, PNND Organometallic chemistry, PNR Physical chemistry, PNRD Catalysis

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