Camptothecins : New Anticancer Agents

Camptothecins are synthetic and semi-synthetic derivatives of a plant alkaloid that inhibit a cellular enzyme and trigger a cascade of events leading to programmed cell death.

This book presents a comprehensive overview of clinical trials of camptothecins - a new class of anticancer agents.Special attention is given to the adverse effects of camptothecin treatment, as well as to prevention and control.

The book is intended for researchers in anticancer drug development, and biochemistry and genetics of DNA topoisomerases, as well as experiemtnal and clinical oncologists.