Regulatory genomics: RECOMB 2004 international workshop, RRG 2004, San Diego, CA, USA, March 26-27, 2004, revised selected papers - 3318 (1st ed.)

Research in the ?eld of gene regulation is evolving rapidly in an ever-changing s- enti?c environment.

Microarray techniques and comparative genomics have enabled more comprehensive studies of regulatory genomics and are proving to be powerful tools of discovery.

The application of chromatin immunoprecipitation and microarrays (chIP-on-chip) to directly study the genomic binding locations of transcription factors has enabled more comprehensive modeling of regulatory networks.

In addition, c- plete genome sequences and the comparison of numerous related species has dem- strated that conservation in non-coding DNA sequences often provides evidence for cis-regulatory binding sites.

That said, much is still to be learned about the regulatory networks of these sequenced genomes.

Systematic methods to decipher the regulatory mechanism are also crucial for c- roboratingthese regulatorynetworks.Thecoreof thesemethodsarethe motifdiscovery algorithms that can help predict cis-regulatory elements.

These DNA-motif discovery programsarebecomingmoresophisticatedandare beginningto leverageevidencefrom comparative genomics (phylogenetic footprinting) and chIP-on-chip studies.

How to use these new sources of evidence is an active area of research.