Immunobiology of Bacterial CpG-DNA - 247

Bacterial CpG-DNA sequences not only serve for genetic information but act as "danger" signal to alert immune cells such as macrophages and dendritic cells.

CpG-DNA directly causes activation of these members of the innate immune system yielding in up-regulation of co-stimulatory molecules and pro-inflammatory cytokines.

As such they act as "natural" adjuvants to promote protective Th1 polarized T cell immune responses.

This book is the first comprehensive review of the data emerging in this field.