Heterotypic Cortex

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Heterotypic cortex consists of those areas of the mature neocortex that deviate markedly from the homogeneous six-layered internal structure seen in the third trimester of human gestation.

A few neocortical areas, such as Brodmann area 17 and the granular insular cortex, undergo modification to more than six layers; and in a few areas, such as Brodmann area 4, the number of layers is reduced.

Heterotypic cortex is contrasted to homotypic cortex, which retains the fetal six-layered pattern into adulthood.

The number of heterotypic areas is small and the specific areas differ somewhat by species.