Reversible Mao-A Inhibitors as Antidepressants : Basic Advances and Clinical Perspectives

This text offers a look at a new class of antidepressant drugs: reversible (short-acting) and selective type-A monoamine oxidase (MAO-A) inhibitors.

An assorted collection of preclinical and clinical investigators illustrate several relevant aspects of the MAO-A, dwelling on their antidepressant effects in various subgroups of patients suffering from endogenous, exogenous or atypical depressive disorders. Because of their high tolerance and mild side-effect profile, MAO-A inhibitors appear to have a wider gamut of therapeutic potential in psychiatry than tricyclic antidepressants.

The array of evidence presented in this book demonstrates that the new generation of reversible MAO-A inhibitors are effective antidepressants with less side-effects than available tricyclic antidepressant drugs.