Clinical trial optimization using R

The main goal of this book is to define a unified framework for clinical trial optimization based on a comprehensive quantitative evaluation of relevant clinical scenarios (using the clinical scenario evaluation approach) and introduce best practices for simulationbased optimization.

The book will be aimed at a broad audience and will emphasize a hands-on approach with a detailed discussion of practical issues arising in clinical trial optimization and R software implementation (relevant statistical methodology will be moved to the appendix).