Role of Bone in Acid-Base Regulation : Special Topic Issue: Vol. 20, No. 1-2 (1994) Mineral and Electrolyte Metabolism

Analyzing the bidirectional relationship between bone metabolism and perturbations in systemic acid base, this publication contributes to the understanding of the role of bone in acid-base regulation.

Chapters dealing with the cellular and non-cellular mechanisms of changes in bone composition during acid-base disorders are complemented by descriptions of how individual bone cells, osteoblasts and osteoclasts, regulate their own cytoplasimc pH(pHi).

This has so far not been described in the context of the overall response of bone to perturbed acid-base balance.

Finally, Dr. Charles R. Kleeman, a world-renowned expert in the field of divalent ion metabolism, investigates the effects of chronic acidosis on the skeleton and provides a comprehensive review of the currently available literature related to the role of acidosis in the pathogenesis of azotemic ostrodystrophy.