High-throughput screening in drug discovery

After several years of little progress, high throughput screening is now experiencing a tremendous boost by embracing the novel concepts of chemical genetics and chemoinformatics.

The time is ripe for a fresh look on the field. "High-Throughput Screening in Drug Discovery" provides both academics and professionals in the pharmacology and biotechnology industry with a guide for successful compound screening in pharmaceutical research and chemical biology.

This timely reference discusses the rationale behind successful and "intelligent" screening approaches and presents current methods and technologies for assaying bioactive molecules in a high-throughput situation.

In addition, it treats in detail the analysis of the data generated in the assay and chemoinformatics support for high-throughput data management, a facet that is often neglected but is of tremendous practical importance.