Molecular Mechanism of Biosignal Transduction

Rapid and extensive progress in studies on the biosignal transduction mechanism has greatly enhanced the understanding of the mechanisms of hormonal regulation, neuronal transmission and growth regulation, including carcinogenesis.

The aim of the 23rd Gunma Symposium on Endocrinology was to survey these newly discovered aspects of cellular regulation systems. This Proceedings volume contains papers presented by researchers recognized for their pioneering work in this field.

Presented articles cover the regulatory functions of guanine nucleotide binding proteins, the role of proteinkinase C in growth regulation and the cytoskeletal regulation by calmodulin binding proteins.

The importance of the newly identified plasma membrane receptors as well as nuclear receptors in neuronal cells for thyroid hormones are discussed.

Further articles describe the details of the cytoplasmic receptor complex for estradiol and the nuclear response to the steroid.

In addition the biochemistry of membrane phospholipids and glycolipids are also reviewed.