Neuroimmunomodulation: Molecular Aspects, Integrative Systems, and Clinical Advances : Papers Presented at a Conference Entitled "Third International Congress of the International Society for Neuroimmunomodulation" Held by the International Society for Neuroimmunomodulation on November 13-15, Bethesda, 1996

The discipline of neuroimmunomodulation is devoted to interactions between the immune nervous systems at all levels and includes observation on brain, pituitary, peripheral nervous system and immune cells.

Nitric oxide synthase is contained within neurons in the brain and modifies behavioural and hormonal responses by acting on other neurons and on release of peptides and other transmitters through activation of guanylate cyclase and cyclooxygenase.

Increases in this and in expression of proinflammatory cytokines can contribute to damage in patients with multiple sclerosis, Parkinsonism, meningitis, stroke, and Alzheimer's disease.