Generation of Antibodies by Cell and Gene Immortalization : BIOTECH 92: International Symposium on New Generation of Monoclonal Antibodies in Diagnosis and Therapy, Genoa, April 1992

A major focus in current immunology research is on overcoming the problems that are encountered when antibodies raised in mice are used to treat human diseases such as cancers.

Many of the various approaches to these problems are covered by contributions to this book: cloning of specific antibody fragments and antibody reshaping in bacteria and phage, the generation of heteromyelomas, and the design of transgenic mice to produce human antibodies.

A section of the book is also devoted to bispecific antibodies.

Potential applications of several of these novel antibodies in the treatment of breast cancer, colorectal carcinomas and autoimmune disorders are thoroughly discussed.

The book documents not only basic approaches in the development of new antibodies, but also illustrates the promising results being obtained with engineered antibodies in clinical settings.