Hyperkalemic Periodic Paralysis

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Hyperkalemic periodic paralysis (HYPP, HyperKPP) is a genetic disorder which occurs in both humans and horses, where it is also known as Impressive Syndrome.

It is an inherited autosomal dominant disorder which affects sodium channels in muscle cells and the ability to regulate potassium levels in the blood.

It is most commonly associated with horses, but also occurs in humans, where it may be called Gamstorp episodic adynamy.

It is characterized by muscle hyperexcitability or weakness which, exacerbated by potassium or cold, can lead to uncontrolled shaking followed by paralysis.

Onset in humans usually occurs in the twenties.