The Philadelphia chromosome: a mutant gene and the quest to cure cancer at the genetic level

The discovery of a cancer-causing genetic mutation leads to a lifesaving miracle drug in this "absorbing, complex medical detective story" (Kirkus Reviews).

Philadelphia, 1959. A scientist scrutinizing a single human cell detects a missing piece of DNA. That scientist, David Hungerford, has just stumbled on the starting point of modern cancer research?the Philadelphia chromosome.

It would take doctors and researchers around the world more than three decades to unravel the implications of this landmark discovery. In 1990, the Philadelphia chromosome was recognized as the sole cause of a deadly blood cancer, chronic myeloid leukemia, or CML. Cancer research would never be the same.

With extensive research and numerous personal interviews, science journalist Jessica Wapner reconstructs the decades-long journey from Hungerford's discovery to a breakthrough, lifesaving treatment. A chronicle of scientific rigor and determination, The Philadelphia Chromosome celebrates a rare triumph in the battle against cancer while offering a blueprint for future research.

One of The Wall Street Journal's 10 Best Nonfiction Books of 2013