Guidelines for Preclinical Evaluation and Clinical Trials in Osteoporosis

This text provides guidelines for the design, implementation, and interpretation of preclinical studies and clinical trials of agents undergoing investigation for the management of osteoporosis.

It opens with a brief discussion of the public health problem caused by ostoporotic fractures, followed by conceptual and operational definitions of osteoporosis and a recommended classification of four intervention categories that facilitate the definition of treatment objectives and the design of targetted studies.